Friday, January 4, 2013

COMPUTER GENERATIONS | Pak Pakistan

There is continuous advancement going on in computing and computers. Thousands of researchers and scientists are working to improve the performance and user experiences of computers. Historically there have been five major technological developments that changed the way computers operate.

First Generation (1940 to 1956)

  • Main technology ? vacuum tubes
  • Technology used for memory ? magnetic drums
  • Programming language ? machine language, the lowest-level programming language understood by computers
  • Input mechanism ? the inputs were relied on punched cards
  • Output mechanism ? the outputs of these computers were displayed on printouts
  • Drawbacks
    • Very large in size (normally occupied the space of a room)
    • Less energy efficient (used a large amount of energy)
    • Offered less computing functions
    • Produced large amounts of heat
    • Frequent malfunctions
    • More expensive
    • Single tasking (could not perform/solve multiple operations)
  • Popular examples of first generation computers include UNIVAC and ENIAC computers. UNIVAC was first sold to US Census Bureau (a business client) in 1951.

?Second Generation (1956-1963)

  • Main technology ? transistors (invented in 1947)
  • Input and output mechanisms ? ?same as that for the first generation computers.
  • Programming languages ? assembly language
  • Magnetic core technology was used for memory
  • Advantages over first generation ? smaller, faster, cheap, energy efficient and reliable
  • First computers were developed for the atomic energy industry.

Third Generation (1964-1971)

  • Technology used ? Integrated Circuits (Semiconductors made of transistors placed on silicon chips increased the speed and efficiency)
  • Input mechanism ? keyboards
  • Output mechanism ? monitors
  • User interface ? Operating System
  • Main advantages
    • Reduced size
    • Reduced costs
    • Improved user experience
    • Operating systems enable the device to run many different applications
    • Accessible by large public because of their reduced size and costs

Fourth Generation (1971-Present)

  • Technology ? Microprocessors (thousands of integrated chips on a single silicon chip)
  • First time introduction of Graphical User Interface ? GUI
  • First time use of mouse and many other input/output devices
  • Intel 4004 chip, developed in 1971 was the first widely popular chip. It located central processing unit, memory and input/output controls on a single chip
  • First computer for the home users was introduced by IBM in 1981
  • Macintosh introduced by Apple in 1984
  • Advantages:
    • Small size Size ? The big room size computers of first generation could be accommodated by a single chip in the palm of hand
    • Tremendous decrease in costs and size
    • More user friendly ? easy to use
    • Computing power improved tremendously and this enabled networking of computers and different nodes

Fifth Generation (Present and Beyond)

  • Technology used ? Artificial Intelligence (still in development)
  • Parallel processing and superconductors are being used to make artificial intelligence a reality
  • It is highly believe that use of quantum computation and molecular and nanotechnology will introduce landmark changes in the way computers operate and being used
  • Main advantage
    • To make computing devices intelligent enough to understand and respond to natural language
    • Capable of learning and self-organisation
    • To improve computation resources

Source: http://www.pakpakistan.org/computer-generations/

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Thursday, January 3, 2013

Research uncovers new insight into cell development and cancer

Wednesday, January 2, 2013

Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.

The study, published December 27, 2012 by the journal Molecular Cell, implicates a unique class of proteins called polycomb-like proteins, or PCL's, as bridging molecules between the "on" and "off" state of a gene. While all of these specialized types of cells share the same genetic information encoded in our DNA, it is becoming increasingly clear that information outside the genome, referred to as epigenetics, plays a central role in orchestrating the reprogramming of a stem cell down a defined path.

Although it is understood that epigenetics is responsible for turning genes "on" and "off" at defined times during cellular development, the precise mechanisms controlling this delicate process are less well understood.

"This finding has important implications for both stem cell biology and cancer development, as the same regulatory circuits controlled by PCL's in stem cells are often misregulated in tumors," said Dr. Greg Wang, senior author of the study and Assistant Professor of Biochemistry and Biophysics in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center.

The study, led by postdoctoral research fellows Drs. Ling Cai and Rui Lu in the Wang lab, and Dr. Scott Rothbart, a Lineberger postdoctoral fellow in the lab of Dr. Brian Strahl, Associate Professor of Biochemistry and Biophysics in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center, identified that PCL's interact with an epigenetic signal associated with genes that are turned on to recruit a group of proteins called the PRC2 complex which then turn genes off.

"In stem cells, the PRC2 complex turns genes off that would otherwise promote reprogramming into specialized cells of organs like the heart or lungs," said Wang.

In addition to its fundamental role in cellular development, elevated levels of PRC2 have been found in cancers of the prostate, breast, lung, and blood, and pharmaceutical companies are already developing drugs to target PRC2. Wang and colleagues determined that the same mechanisms controlling PRC2 function in stem cells also applies in human cancers.

"The identification of a specific PCL in controlling PRC2 in cancer cells suggests we may be able to develop drugs targeting this PCL to regulate PRC2 function in a more controlled manner that may maintain PRC2 function in stem cells while inhibiting it in the tumor," said Wang.

###

University of North Carolina Health Care: http://www.med.unc.edu

Thanks to University of North Carolina Health Care for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 50 time(s).

Source: http://www.labspaces.net/126096/Research_uncovers_new_insight_into_cell_development_and_cancer

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?American Idol? Winner Kris Allen & Pregnant Wife In Bad Car Accident

“American Idol” Winner Kris Allen & Pregnant Wife In Bad Car Accident

American Idol star Kris Allen and wife Katy expecting first child“American Idol” winner Season 8 Kris Allen was in a head-on collision on January 1, 2013, that landed him and his pregnant wife Katy in the hospital. The “Live Like We’re Dying” singer’s mother, Kimberly Allen, tweeted a picture of her son in the hospital, writing, “Kristopher and Katy are both pretty beat up but ...

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Wednesday, January 2, 2013

Adding Shower Attachments To Your Home Improvement Plan

Adding shower attachments to your bath could be just what you need to bring a better experience to a bath. These fixtures can improve the quality of bath time, and the new units can be an affordable luxury once installed. When you see the products available, you may be surprised at your options and the products that could work for you to give your home a simple yet useful upgrade.

These types of accessories can give new life to your bath scene for not a lot of money. You can think about different upgrades that you would like to experience in the space. Also consider new accessories for an instant makeover in a bathroom at an affordable price.

Italian faucets can bring an instant sense of style and elegance to a bathroom space once installed. You could enjoy comparing the different styles and models available that you could add for an entirely new look. These faucets can be just what you need to pull the rest of the room together.

Different shower body sprayers can intensify the water pressure in your bath without using more water and causing your water bill to rise. New models today typically are designed to maximize efficient water usage while still being conservative. Newer varieties could start to save you dollars on your monthly water bills once installed and used on a regular basis.

Finding newer fixtures that you like can help you address current challenges you might face with existing units in your bathroom space. Old, discolored or leaking faucets can be switched out with newer, shinier models that complement the surroundings. Just seeing the newer varieties may cheer you up each time you walk into the space.

This home-improvement strategy could be a money-saving way to bring new detailing to your bath space. You can skip tearing up your entire bath and wholesale replacing tubs or sinks with just an easy makeover of updated fixtures. This strategy can make sense if you are trying to stretch your budget while improving your home.

Shower attachments can transform a plain bath space into a luxurious experience each time you use it. Spend some time looking at your options and consider what would work best in your space and for your needs. For a quick and seamless upgrade, these fixtures could be the perfect solution in your home.

People who like quick showers may be interested in a variety of shower attachments. They can enjoy their showering experience when they include Italian faucets in their designs.

Source: http://www.bromshirespost.com/family/adding-shower-attachments-to-your-home-improvement-plan.htm

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Senate passes 'fiscal cliff' deal, House up next

With 2013 just over two hours old, the Senate voted 89-8 on Tuesday to approve a last-minute deal to avert income tax hikes on all but the richest Americans and stall painful spending cuts as part of a hard-fought compromise to avoid the economically toxic ?fiscal cliff.?

The country had already technically tumbled over the cliff by the time the gavel came down on the vote at 2:07 a.m.. The House of Representatives was not due to return to work to take up the measure until midday on Tuesday. But with financial markets closed for New Year's Day, quick action by lawmakers would likely limit the economic damage.

The lopsided margin belied anxiety on both sides about the deal, which emerged from barely two days of talks between Vice President Joe Biden and Republican Senate Minority Leader Mitch McConnell. Among the ?no? votes: Republican Senator Marco Rubio, widely thought to have his eye on the 2016 presidential race.

In remarks just before the vote, McConnell repeatedly called the agreement ?imperfect? but said it beat allowing income tax rates rise across the board.

?I know I can speak for my entire conference when I say we don?t think taxes should be going up on anyone, but we all knew that if we did nothing they?d be going up on everyone today,? he said. ?We weren?t going to let that happen.?

?Our most important priority was to protect middle-class families. This legislation does that,? Democratic Senate Majority Leader Harry Reid said. But Reid cautioned that ?passing this agreement does not mean negotiations halt. Far from it.?

Compromises on tax rates

Under the compromise arrangement, taxes would rise on income above $400,000 for individuals and $450,000 for households, while exemptions and deductions the wealthiest Americans use to reduce their tax bill would face new limits. The accord would also raise the taxes paid on large inheritances from 35% to 40% for estates over $5 million. And it would extend by one year unemployment benefits for some two million Americans. It would also prevent cuts in payments to doctors who treat Medicare patients and spare tens of millions of Americans who otherwise would have been hit with the Alternative Minimum Tax.

The middle class will still see its taxes go up: The final deal did not include an extension of the payroll tax holiday. And the overall package will deepen the deficit by hundreds of billions of dollars by extending the overwhelming majority of the Bush tax cuts. Many Democrats had opposed those measures in 2001 and 2003. Obama agreed to extend them in 2010.

Efforts to modify the first installment of $1.2 trillion in cuts to domestic and defense programs over 10 years -- the other portion of the ?fiscal cliff,? known as sequestration -- had proved a sticking point late in the game. Democrats had sought a year-long freeze but ultimately caved to Republican pressure and signed on to just a two-month delay while broader deficit-reduction talks continue.

Debt-limit battle looms

That would put the next major battle over spending cuts right around the time that the White House and its Republican foes are battling it out over whether to raise the country's debt limit. Republicans have vowed to push for more spending cuts, equivalent to the amount of new borrowing. Obama has vowed not to negotiate as he did in 2011, when a bruising fight threatened the first-ever default on America's obligations and resulted in the first-ever downgrade of the country's credit rating. Biden sent that message to Democrats in Congress, two senators said.

Experts had warned that the fiscal cliff's tax increases and spending cuts, taken together, could plunge the still-fragile economy into a new recession.

Biden, evidently in good spirits after playing a central role in crafting the deal, said little on his way into or out of a roughly one hour and 45 minute meeting behind closed doors with Senate Democrats. "Happy New Year," he said on the way in. Asked on the way out what his chief selling point had been, the vice president reportedly replied: "Me."

Biden's intervention; hurdles in the House

Hours earlier, a Democratic Senate aide told Yahoo News that "the White House and Republicans have a deal," while a source familiar with the negotiations said President Barack Obama had discussed the compromise with Reid and Democratic House Minority Leader Nancy Pelosi and "they both signed off."

But the House?s Republican leaders, including Speaker John Boehner, hinted in an unusual joint statement that they might amend anything that clears the Senate ? a step that could kill the deal.

?Decisions about whether the House will seek to accept or promptly amend the measure will not be made until House members -- and the American people -- have been able to review the legislation,? they said.

Biden, a 36-year Senate veteran, worked out the agreement with McConnell after talks between Obama and Boehner collapsed and a similar effort between McConnell and Reid followed suit shortly thereafter. With the deal mostly done, Obama made a final push at the White House.

?Today, it appears that an agreement to prevent this New Year's tax hike is within sight, but it's not done,? Obama said in hastily announced midday remarks at the White House. ?There are still issues left to resolve, but we're hopeful that Congress can get it done ? but it?s not done.?

"One thing we can count on with respect to this Congress is that if there is even one second left before you have to do what you?re supposed to do, they will use that last second," he said.

Obama?s remarks ? by turns scolding, triumphant, and mocking of Congress ? came after talks between McConnell and Biden appeared to seal the breakthrough deal.

?I can report that we?ve reached an agreement on all of the tax issues,? McConnell said on the Senate floor moments later. ?We are very, very close to an agreement.?

The Kentucky Republican later briefed Republicans on the details of the deal. Lawmakers emerged from that closed-door session offered hopeful appraisals that, after clearing a few last-minute hurdles, they could vote on New Year?s Eve or with 2013 just hours old.

?Tonight, I hope,? Republican Senator Bob Corker of Tennessee told reporters. ?It may be at 1, 2, 3, 4 in the morning. Oh, I guess that?s technically tomorrow.?

Reckoning with the 'sequester'

Republican Senators said negotiators were still working on a way to forestall two months of the ?sequester? spending cuts, about $20 billion worth. And some expressed disquiet that the tentative compromise ran high on tax increases and low on spending cuts -- while warning that failure to act, triggering some $600 billion in income tax increases on all Americans who pay it and draconian spending cuts, was the worse option.

McConnell earlier had called for a vote on the tax component of the deal.

?Let me be clear: We?ll continue to work on finding smarter ways to cut spending, but let?s not let that hold up protecting Americans from the tax hike,? McConnell urged. ?Let?s pass the tax relief portion now. Let?s take what?s been agreed to and get moving.?

House passage was not a sure thing: Both the AFL-CIO labor union and the conservative Heritage Action organization argued against the package.

The breakthrough came after McConnell announced Sunday that he had started to negotiate with Biden in a bid to "jump-start" stalled talks to avoid the fiscal cliff.

Under their tentative deal, the top tax rate on household income above $450,000 would rise from 35 percent to 39.6 percent -- where it was under Bill Clinton, before the reductions enacted under George W. Bush in 2001 and 2003.

Some congressional liberals had expressed objections to extending tax cuts above the $250,000 income threshold Obama cited throughout the 2012 campaign. Democrats were huddling in private as well to work out whether they could support the arrangement.

Obama responds to critics

Possibly with balking progressives in mind, Obama trumpeted victories dear to the left of his party. "The potential agreement that?s being talked about would not only make sure the taxes don?t go up on middle-class families, it also would extend tax credits for families with children. It would extend our tuition tax credit that?s helped millions of families pay for college. It would extend tax credits for clean energy companies that are creating jobs and reducing our dependence on foreign oil. It would extend unemployment insurance to 2 million Americans who are out there still actively looking for a job."

Obama said he had hoped for "a larger agreement, a bigger deal, a grand bargain," to stem the tide of red ink swamping the country?s finances ? but shelved that goal.

"With this Congress, that was obviously a little too much to hope for at this time," he said. "It may be we can do it in stages. We?re going to solve this problem instead in several steps."

The president also looked ahead to his next budgetary battle with Republicans, warning that ?any future deficit agreement? will have to couple spending cuts with tax increases. He expressed a willingness to reduce spending on popular programs like Medicare, but said entitlement reform would have to go hand in hand with new tax revenues.

?If Republicans think that I will finish the job of deficit reduction through spending cuts alone ? then they?ve another thing coming,? Obama said defiantly. ?That?s not how it?s going to work.?

?If we?re serious about deficit reduction and debt reduction, then it?s going to have to be a matter of shared sacrifice. At least as long as I?m president. And I?m going to be president for the next four years, I hope,? he said.

The other ?no? votes were: Michael Bennet (D-Col.), Tom Carper (D-Del.), Chuck Grassley (R-Iowa), Tom Harkin (D-Iowa), Mike Lee (R-Utah), Rand Paul (R-Ken.), and Richard Shelby (R-Ala.). Republicans Jim DeMint of South Carolina and Mark Kirk of Illinois as well as Democrat Frank Lautenberg of New Jersey did not vote.

Source: http://news.yahoo.com/blogs/ticket/senate-passes--fiscal-cliff--deal--house-up-next-082813845.html

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Tuesday, January 1, 2013

Day 1 of the January Money Diet ? Shop at Home | Happy Simple ...

January Money Diet at Happy Simple Living blog

Photo: J Luoh

Welcome to the first day of the January Money Diet. I?m so glad you?re taking part in this challenge. It?s simple, really; we just take a 31-day break from all nonessential spending ? and pocket the savings. Each day, I?ll post an idea that supports the idea of having a happy, interesting, frugal but fun-filled month ? all without spending a nickel. New this year, we?ll have daily homework assignments to keep us all accountable.

On this first day of the January Money Diet, begin by doing some ?shopping? at home. This is the perfect time to go through the closets and drawers looking for those unused things we all tend to save for Someday.

Start in the pantry and freezer; do you have any fancy, gourmet items or forgotten goodies lurking back in the shelves? In my own kitchen, I did some excavating and brought forth a jar of lemon curd, spice mixes, coconut milk, instant espresso powder and more. This month I?m going to find creative ways to use these products; I?ll spoil my family a bit, and clear some room in the cabinets and freezer at the same time.

What about those specialty kitchen appliances and gadgets gathering dust? For instance, we have a paella pan, a tortilla press and an ice cream cone maker that I plan to put into service this month.

Another place to ?shop? at home is the bathroom cabinet; are there shampoo samples, fancy soaps, loofahs, pedicure kits and scented bath salts languishing in your cabinets? Gather ?em up and plan to use them. If not this month, when?

What about those unused craft and scrapbooking supplies? And home improvement materials? Fabric and sewing supplies? Yarn and knitting needles? Blank CDs? Office supplies? Candles? Art supplies? Check your medicine chest, too; are there vitamins and supplements languishing there? Take a look around the closets and drawers of your home, and you might find a treasure trove just waiting to be used up and enjoyed.

Homework Assignment #1: Go on a scavenger hunt at home, and make a list of products you already have that you plan to use this month. Post some highlights from what you find in the comments section below. You know we?re all just dying to know what you unearth.

It?s a glorious new year, my friends ? so wear your silk pajamas! Light the vanilla-scented candles, raid the liquor cabinet and drink the fancy brandy!

From our home to yours, we wish you a happy, healthy and prosperous 2013. May these next 30 days be the beginning of your best year ever.

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I?ll be giving away a gift basket chock-full of home and garden goodies plus several other prizes on January 31, 2013. Every time you post your homework assignment or comment during January, you?re automatically entered for the drawing. I hope you?ll stop by often this month and share your own ideas, thoughts and experiences.

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About Eliza Cross

Eliza Cross is a full-time writer and the author of five books about home design and food. She has been blogging about simplicity and sustainable living since 2006.

Source: http://www.happysimpleliving.com/2013/01/01/day-1-of-the-january-money-diet-shop-at-home/

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